Henley-based brewer and pub operator Brakspear has bought the Henley Brew House from City Pub Company.
It is now recruiting a tenant to run the pub, which is in Market Place, from November onwards. The former brewery will be removed to make more space, although Brakspear has said the site will still focus on quality beer, by selling varieties brewed round the corner at its own historical Bell Street brewery.
Brakspear chief executive Tom Davies commented on the new buy, saying: "We're pleased to add the Brew House to our stable of successful pubs in our Henley heartland. With the right tenant at the helm, we're confident the pub will trade well and attract customers into Henley."
Brakspear was originally started as a brewery in Henley in 1711, and its first pub, the Cross Keys in Witney, was opened in 1769.
The company now runs more than 140 pubs around the south of the UK, including the Owl & Pussycat in London's Shoreditch, the Crown in Reading, the Quayside in Whitstable, the Rising Sun in Thame, and the Red Lion in Didcot.