Pub firm and brewer Greene King is set to open its first station pub as part of the Euston station balcony development scheme.
The company won the contract through a competitive tender awarded by Network Rail Property, and it will run for nine years.
Greene King said it would invest a seven-figure sum and that the pub would be known as the Duke of Grafton - named after the owner of the land that the original Euston station was built on.
The Duke of Grafton will be based on Greene King's Metropolitan Pub Company format.
The company's move follows the success of the Parcel Yard in King's Cross - a new station pub run by rival operator Fuller's.
Rooney Anand, Greene King's chief executive officer, said: "It is an exciting time to be developing a pub in a station with rail passenger numbers growing every year and investment in rail network and the major stations also increasing.
"Stations are a hub of activity and we want to offer rail users a place to eat, drink, meet and work in a relaxed atmosphere where they can enjoy a quality pub experience. This latest development will provide a ‘home from home' for those living in London as well as those working or visiting the capital."