Meantime Brewing Company is expanding its Greenwich facility, quadrupling production capacity.
The move, which also involves the creation of a brand new visitor centre and shop, will make it the largest craft brewery in London.
The changes are expected to be completed in May 2012.
The expansion will lift Meantime Brewing Company's capacity from its current 25,000 hectolitres per year to over 100,000 hectolitres annually. This means the expanded brewery will be able to produce over 1.5 million pints every month across its range of keg and bottled beers.
Meanwhile, the new visitor centre will be fully operational in time for the London Olympics. This, alongside the daily brewery tours for visitors, will showcase London's brewing history, as well as giving a wider audience an understanding of the company's approach to beer making.
Meantime will also host beer and food matching events at the visitors' centre, giving trade customers and consumers a taste for the beers that partner food.
Nick Miller, chief executive of Meantime Brewing Company, said: "At Meantime, we want to challenge the notion that beers made in the craft tradition can only be made by small-scale brewers. We don't think the craft category should be defined by the size of the brewer, but by the approach of the brewmaster and his team, the ingredients, the range of beer styles and ultimately, the way the beers taste.
"We believe the future of craft lies in offering diversity and variety in beer. We will achieve that by continuing to offer choice through different styles of beer, by taking authentic recipes and making them better using the most advanced techniques and finest ingredients. We have big ambitions for the business and think this approach will enable us to achieve them."
"Our new brewery will make our core range of beers, but we will not stop there. Meantime has always been innovating in the beer category and I, along with my team, plan to keep creating new, interesting styles that really push people's perceptions of the tastes that great beers can deliver. I intend to make sure that Meantime's London brewery remains the best and most innovative because beer drinkers of the future will demand that of us."
By Neil Gerrard
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Published by: The Caterer