The two-year deal, worth about £1.5m, will see Sceptre supply more than 450 machines to roughly half of Thwaites' managed and tenanted estate.
This follows a new contract, agreed in February 2011, to supply 200 machines to SA Brains in Cardiff.
Sceptre's chief executive, Ken Turner, said: "The new Thwaites deal underlines the close working relationship developed between our two companies over more than 12 years and we are delighted to be able to continue this association.
"Coupled to our recent contract win for new business from Brains, I believe this demonstrates that Sceptre continues to offer the most innovative and customer-focused coin-op solutions available to pub operators across the UK."
By Neil Gerrard
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