Up to 200 people were caught partying at the Richmond hotel in Liverpool's Hatton Garden on the weekend.
At around 3.15am on Sunday 31 January, officers attended at the hotel and estimated that between 150 and 200 people were present across four separate parties with evidence of drug use.
Officers removed everyone who was not a legitimate guest within the hotel. Thirteen fixed penalty notices were issued and 11 documented warnings were given.
One woman was arrested for breaching coronavirus legislation and for two counts of assaulting a constable. One man at the location was arrested as he wanted for a No Bail Warrant.
In addition, three community resolutions were issued for drugs and 20 people were stop searched under the Misuse of Drugs act.
Merseyside Police chief superintendent Matt Boyle said: "We are currently in a national lockdown which means people should not be leaving their homes for non-essential reasons or meeting up with other people outside their household or support bubble.
"This sort of behaviour is unbelievable and unacceptable and officers should not be confronted with abuse and violence when attempting to uphold the law which most people are rightly abiding by.
"I would continue to ask people to please consider their own safety and that of their loved ones. We are all in this together and the laws apply to everyone.
"We all need to do everything we can to protect the NHS and our frontline staff during this deadly pandemic and we will not hesitate to take action when we believe people are flouting the rules."