Mitie has been awarded a £150m multi-service facilities management contract extension with St George's University Hospitals NHS Foundation Trust.
The group has been working with St George's since 2009 and has had its contract extended until 2030.
Mitie, which already provides a range of services including cleaning, patient catering and facilities helpdesk services, will also take on waste management duties across the site in Tooting, London, which serves more than one million patients a year.
Mitie and St George's have also committed to increase pay so that Mitie staff receive at least the London Living Wage of £10.55 an hour.
Investment by Mitie will deliver service enhancements as part of the new contract, for example, new digital touch screens to enable hospital staff to place and monitor cleaning and catering requests.
A new electronic system will allow patients to view nutritional and allergen information while ordering their meals, which will also monitor food wastage.
St George's University Hospitals NHS Foundation already boasts an award-winning British Institute of Cleaning Science Training Centre (BICSc) on site. In addition, Mitie's investment will include the development of a dedicated training centre to create the catering equivalent.
Jacinto Jesus, director of healthcare, cleaning and environmental services, Mitie, said: "Hospitals are challenging environments in which to deliver facilities management and we are proud to continue our partnership by extending our long-term relationship with St George's hospital. As well expanding our services to include waste management, we are investing in the latest technology as well staff recognition and development, to ensure service excellence in support of the critical work that hospital staff carry out every day."
Andrew Grimshaw, deputy chief executive and chief financial officer at St George's, said: "We are pleased to have awarded the contract to Mitie, and we look forward to continuing our relationship with them, whilst also looking at new and improved ways of delivering these vital support services for patients, staff, and the communities we serve."