French company Accor is set to lose some 230 employees, while Hilton confirmed it will cut 100 jobs.
Accor, which operates the Ibis and Novotel brands, said will cut 10% of its workforce at its head offices and Hotellerie France head offices as it looks to make a 15% reduction in support costs.
The company said the hotel business continues to be impacted by the effects of an "unprecedented worldwide crisis".
"This has led to a decline in first-quarter 2009 business and shows no prospects for improvement in the short term," Accor said.
"Based entirely on voluntary departures, the two-part plan would concern around 230 positions in France."
Accor has also cut costs in other areas, including curbing renovation spending for this year by €170m (£147m), as well as hotel development spending next year by €120m.
Meanwhile, Hilton confirmed that it would lose around 100 employees this month after a three-month consultation period.
A spokeswoman for the hotel group said: "The restructuring is part of Blackstone's realignment. It's not about stripping out costs for us but moving towards a new functional structure driven from the USA."
The restructure is being pushed through by Christopher Nassetta, appointed president and chief executive after private equity firm Blackstone's $26b (£16b) buyout of Hilton in October 2007.
By Gemma Sharkey
E-mail your comments to Gemma Sharkey here.
Looking for a new job? Find your next hotel job here with Caterersearch.com jobs