Assured Hotels is taking over the operation of Cleveland Tontine at Staddlebridge in North Yorkshire.
Originally established in the 1800s as a turnpike inn, the seven-bedroom property, which has a five-star rating from the AA in its restaurant with rooms category, gained prominence under the ownership of the McCoy brothers from 1976 to 2013.
The business was acquired three years ago by regular customers Charles and Angela Tompkins, who have since invested over £1m, making improvements to the building's fabric and interiors.
Assured Hotels' managing director Mike Rothwell said: "The owners have invested well in this property and it has a strong following in the local area."
The company plans to improve the hotel's facilities by increasing the use of private dining rooms.
"It's our job to build on the foundations and take it onwards and upwards," said Rothwell.
Assured has appointed Stephane Leyreloup as manager. Her experience includes twelve years with Devonshire Hotels as brasserie manager of the Devonshire Arms at Bolton Abbey and manager of the Devonshire Fell boutique hotel.
Leyreloup said: "There's a loyal team in place and James Cooper is a very talented chef. Our job now is to drive the business forward on behalf of the owners."
Cleveland Tontine is the seventh hotel to come under the full management of Assured Hotels. The new venture comes weeks after the company took over management of four-strong Yorkshire hotel group Cedar Court. Assured also work with 40 hotels in the UK in an advisory capacity.