The Four Seasons hotel in Canary Wharf, London, is to be sold by owners Capitaland.
Currently believed to be under offer, the 142-bedroom, five-star hotel will continue to be run by the Four Seasons under a 50-year management contract.
A spokesman for the hotel said it would be business as usual and the deal would not affect the running of the property.
Industry insiders remained tight-lipped about the value of the sale, but it is rumoured to be in the region of £55m.
Capitaland, the investment arm of the Singaporean government and agents CBRE, who are handling the sale, declined to comment.