Deloitte has been handling the administration of the Imperial Property Company (Cardiff 2), and property company Christie & Co has now been appointed to market the hotel.
Located opposite the St David 2 Retail Development, the 21-storey hotel offers the Italian-focused Filini restaurant, the Filini Bar and Lounge and a recently completed conference wing.
Jeremy Hill, director and head of hotels for Christie & Co, said: "Since opening in 2009, the Radisson Blu Hotel has quickly established itself as one of Wales's premier four-star hotels - and it has the potential to grow still further. Cardiff's hotel market was one of the few regional markets to show growth in 2012 and with its array of superb demand generators is well positioned to take advantage of further economic recovery."
Paul Evans, director of Deloitte, said that with sales having exceeded forecasts so far in 2013, now was a good time to sell the hotel. "When we took over the operation of the hotel in 2010 our main focus was to complete the hotel to a quality four-star hotel," he explained.
"We managed to achieve this in 2011 and with the support of Radisson Blu, the staff and our customers, we have managed to increase sales by 30.4% year-on-year."
Offers are being invited for the freehold of the hotel, which comes with the benefit of Carlson Rezidor's Radisson Blu management and branding.