The 111-bedroom Bay Torbay hotel in Torquay will be closed this weekend for a "deep clean" following an outbreak of the sickness and diarrhoea bug norovirus.
At least 12 people fell ill after staying at the hotel, according to reports from the BBC.
Reviews have appeared on TripAdvisor with guests claiming they had a terrible Easter break at the hotel when they were "violently ill with sickness and diarrhoea".
The hotel will be closed from Friday to Monday while the cleaning takes places.
A spokesperson for the Bay Torbay hotel said: "We have chosen to close the hotel for a short period this weekend as a precautionary measure so that we can carry out a deep clean.
"All guests who were due to arrive on Friday will be relocated to a sister hotel close by, and the Bay Torbay hotel will be reopen as usual from Monday onwards."
A small number of bays have been closed at Torbay Hospital, Paignton Community Hospital and Totnes Community Hospital after an increase in norovirus cases.