Planning permission for a 452-bedroom hotel with a green "living roof" on the Greenwich Peninsula has been granted by officials in the London borough.
The luxury hotel, which will have a ballroom, special events space, restaurant, meeting rooms and health spa, is being developed by 02 arena owner AEG.
The hotel, which will feature a sky-bar and executive lounge overlooking the Thames, will incorporate solar panels as part of the roof.
The project, which will now go to the mayor's office for approval, will also incorporate 100 serviced apartments.
Greenwich councillor Denise Hyland said: "Greenwich Peninsula continues in its transformation, with the prospect of this new development.
"This will be the first four-star-plus hotel east of Tower Bridge on this side of the river and will have a ballroom double the size of the Grosvenor House hotel in London."
By Chris Druce
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