Hilton International is to take over the four-star London Euston Plaza Hotel at the beginning of November.
The 150-bedroom property was previously operated by London Plaza Hotels.
The deal will take the number of Hilton hotels in the London area to 17.
The Hilton London Euston, as it will be renamed, is close to Euston, Kings Cross and St Pancras stations.
It is currently undergoing a complete refurbishment.
Asif Bhatia, chief executive of London Plaza Hotels, said: "This partnership provides a great opportunity for this excellent property to benefit from the global reach and operational expertise of one of the world's most powerful hotel brands."
Buy this week's Caterer magazine for more industry news and analysis