Historic Jamaica Inn on Bodmin Moor, featured in the Daphne du Maurier novel of the same name, is for sale at a guide price of £2m.
The 17-bedroom hotel is up for sale through speciality property firm Christie + Co, as long-time owners John and Wendy Watts have decided to retire.
It has a variety of bedrooms, including several with four-poster beds, a restaurant and café, plus a Smuggling Museum with a gift shop, detailing the area's past. It also still has the original writing desk used by Du Maurier, while some rooms are even said to be haunted.
Originally a coaching inn and built in the 1750s, the hotel used to be known as a refuge for smugglers importing tea to the UK via the Cornish and Devon coasts. It has also been suggested that the inn's name may have come from the amount of rum being smuggled.
Billed as a good stop-off point to attractions such as the Eden Project, Land's End and Falmouth's National Maritime Museum, interest in the hotel is likely to be renewed this year, as a new three-part BBC adaptation of the Du Maurier novel is set to hit TV screens in Easter.
Sister hotel the White Hart in Okehampton is also on the market, at a guide price of £900,000. With 19 bedrooms set in the foothills of Dartmoor National Park, the 17th century inn is equally as historic, and reportedly popular as a conference and wedding venue.
Matthew Smith, director of Christie + Co in Exeter, says: "It's rare when just one hotel of such local historical significance is brought to the market, but in Jamaica Inn and the White Hart Hotel we have two excellent opportunities with a renowned past.
"The family which has owned Jamaica Inn since 1973 are now looking to retire, and given the history, the location and the trading records, we anticipate a great deal of interest."
Jamaica Inn saw controversy in 2008 when it was fined over the poor cleanliness of its kitchens.
Inspectors later confirmed that standards had improved in line with recommendations, and the hotel has since maintained a five star Food Hygiene Rating award from the Food Standards Agency.