Previously deputy chief executive, Guile has been credited with masterminding the development of two new build hotels at a cost of £60m and overseeing an investment programme of £200m at the company's four and five-star hotels.
Guile said: "Being offered the opportunity to develop a brand like ours is both an honour and a challenge but one I welcome. I will be supported by a strong team with broad experience of the hotel sector."
Guile worked at Forte and Heritage hotel groups before joining Macdonald Hotels in 2000.
Initially regional managing director for the South of England he was promoted to deputy chief executive in March 2006 and joined the group's board three months later.
Macdonald was named as AA group hotel of the year in September 2007.
By Chris Druce
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