The Edition hotel currently under development in London could be sold by Marriott to fund further expansion of the brand.
Originally the Berners hotel, the site was bought by Marriott for a price in excess of £60m in August 2010.
Jason Atherton is set to open a 120-cover restaurant called Berners Tavern in the luxury hotel, which will open this year under the guidance of hotelier and developer Ian Schrager.
The New York Times has reported that a sale of the hotel is to the Abu Dhabi Investment Authority is imminent, with Marriott set to use the funds generated to expand the brand further.
It said that the deal could also include Edition hotels under construction in Miami and New York.
When Marriott bought the 173 bedroom hotel, its president and chief operating officer Arne Sorenson said: "We are delighted to acquire Berners. It is a perfect property for an Edition hotel in London. With its great location and beautiful façade, the building is a perfect canvass for creating a true work of art."
Ian Schrager added: "I am thrilled to be returning to London for an incredibly special and historical building like Berners hotel. I am excited and passionate about creating an authentic and original experience for this special Edition hotel in this gateway city."
The Berners hotel dates back to 1835. The property originally comprised five residential houses and was later converted into a hotel. The layout includes a basement, ground and seven upper floors, and incorporates original architectural features, such as ornate ceilings and a marble-clad reception area.