Located overlooking the River Thames on the South Bank close to the Tate Modern, the hotel will feature an interior inspired by transatlantic ship travel and ocean liner cabins by Tom Dixon of the Design Research Studio.
The hotel's restaurant will be overseen by New York chef Seamus Mullen. He will work alongside executive chef Luke Raymen, in the open kitchen with a wood-fired oven, to create a menu combining the best of British and American food. Meanwhile the bar will be headed by Ryan Chetiyawardana, also known as Mr Lyan.
The hotel will also feature the AGUA Bathhouse & Spa, 5,500sq ft of meeting space across six rooms, and a 56-seat private screening room.
The Mondrian London, which will become the fourth hotel in the brand alongside properties in Los Angeles, New York and South Beach Miami, will be the third property in London from Morgans Hotel Group alongside the Sanderson and St Martins Lane.
Bookings are now being taken for bedrooms, with a preview rate of £165 plus VAT available on selected nights.