Set within a 30-acre estate near Ross-on-Wye, Herefordshire, the 80-bedroom property is not currently open to the public.
The Leadership Trust has used the building to hold courses for business leaders and managers and last year expanded its use, opening it up to weddings, meetings and conferences.
Now, with a greater percentage of its training programmes being delivered elsewhere, it has now decided to sell the property.
However, the Leadership Trust will continue to use Penyard House as its base.
The sale of the freehold of Penyard House is being handled by Christie + Co.