Offers of around £4m are being sought for the 89-bedroom Leopold hotel, one of Sheffield's most prominent independent properties.
The hotel was built in 1800 and was originally a boys' grammar school. It was restored and converted into a boutique property in 2007 by the Ireland-based Prem Group. It is located close to the urban regeneration area of the city centre and offers a restaurant, bar, fitness suite and conference facilities.
Colliers International and Bilfinger GVA have been instructed to sell the 138-year lease of the property, which has the potential to be branded.
Julian Troup, head of UK hotels agency at Colliers International, said: "The Leopold hotel attracts business from Sheffield's corporate market, together with tourist and function-related business. The hotel has good-quality room stock and facilities and is well-positioned to compete in the local marketplace."
David Creamore, director of hotel agency at Bilfinger GVA, added that the hotel is close to the Sheffield Lyceum, the Sheffield O2 Academy and the Crucible Theatre.