Sunborn International is to open a super yacht hotel located at the Royal Victoria docks, next to ExCel London.
Operated by ISS hotel division, Sunborn London will be launched in March with 138 bedrooms and suites over five floors.
The 120m yacht hotel will include a fine-dining restaurant, bar, auditorium and conference rooms.
It originally served as Sunborn Princess at the Naantali Spa in Finland, but having been fully refurbished it will now be run as a London hotel.
Sunborn said it was also planning to open an 189 bedroom yacht hotel in Gibraltar in March, offering offer the first official five-star hotel accommodation on the rock.
ISS facility services director of hotels, Karen Thomson, added: "We are delighted to see the return of Sunborn to London. At ISS we see this as a very exciting opportunity and together with our partners at ExCeL we look forward to providing our guests a totally unique and lasting experience."