Jonray and Peter Sanchez-Iglesias, the brothers who run Casamia restaurant in Bristol, have been named Chefs of the Year in the Good Food Guide 2015.
It also recognised Andre Garrett at Cliveden House in Taplow, Berkshire, with the Restaurant Newcomer of the Year award.
In addition, the guide, which is published next week, has also awarded Birmingham restaurant Carters of Moseley with Readers' Restaurant of the Year.
Commenting on the Chefs of the Year award, Waitrose Good Food Guide consultant editor Elizabeth Carter said: "Over the past couple of years Jonray and Peter Sanchez-Iglesias have grown in stature and I'm really pleased to be able to rank them with the best chefs in the UK in the Waitrose Good Food Guide 2015.
"The brothers have come to understand what people want to eat, put a high premium on seasonality and freshness, and deliver dishes that are vibrantly seasoned, intricately composed and utterly delicious. As a result, Casamia is proud, vital, and very much worth a visit."
Casamia was placed 39th in the Top 50 restaurant listing in the guide.
Peter Sanchez-Iglesias said: "The UK restaurant scene is full of exceptional culinary talent and to be considered as one of the best, and the only top 50 restaurant in Bristol, gives us such encouragement and inspiration to continue pushing boundaries within our kitchen and hopefully one day make number one."
Andre Garrett at Cliveden House came 18th in the guide's Top 50 listing, and Carter commented on the balance exhibited in the cooking. "Every single dish is executed with precise, mutually enhancing harmony," she said. "Dishes here are special, not because they're outlandish or bang on trend, but because quality ingredients are cooked flawlessly."
Garrett added: "Moving from London to the countryside was a big career and personal decision for me, but I have never been happier. The history and glamour of Cliveden House have been a huge inspiration to me - I am always conscious of our guests' expectations when visiting such a grand house, and my food somewhat sits in two camps - respecting the classical traditions, but being light and modern wherever possible, too."
Carter added that Carters of Moseley had been named Readers' Restaurant of the Year due to its "exceptional friendliness, sheer professionalism, value for money and food that is not only delicious but also properly prepared, seasonal and locally sourced".
She said: "I wish every town had a restaurant of this standard. There are some fabulous restaurants in Birmingham, and it's tough to stand out from the crowd - but Carters of Moseley is a fine example of what can be achieved with sheer determination and a modern, fresh outlook."