The San Carlo group is to open a new site on Regent Street in London's St James's this May.
The 130-cover restaurant will be headed by Alberico Penati, whose career includes Ristorante Carpaccio, Harry's Bar at Annabel's, Alberico at Aspinalls and the private members' club, 5 Hertford Street, in Mayfair.
It will serve fine-dining Italian cuisine using seasonal ingredients, many flown in from produce markets across Italy.
The menu will consist of more than 22 seafood dishes alongside antipasti, pizza, pasta and meat from the grill.
The 20-strong San Carlo group has sites in Covent Garden, Piccadilly and Knightsbridge Green in London as well as in Manchester, Birmingham, Liverpool, Bristol, Leeds and Leicester, along with one in Bangkok and one in Qatar.
Managing director Marcello Distefano said: "The Crown Estate's £500m investment in the St James's area has already attracted some of the best names in international cuisine and we are delighted to be a part of this. The fact that we will also be working with Alberico Penati, one of the great Italian chefs, makes this new venture even more exciting."
San Carlo was founded in 1992 by Carlo Distefano and the first restaurant opened in Temple Street, Birmingham. The group has now grown to become a £60m independent restaurant empire.
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