Accor is to open a 202-bedroom Novotel, which will be operated under a lease agreement with Brentford Hotels, a subsidiary of the Pedersen Group.
The mid-scale Novotel London Brentford hotel is currently under construction and will open in early 2015.
Thomas Dubaere, managing director, Accor UK & Ireland said the hotel in Brentford is in an "ideal location" for both business and leisure travellers. "It further strengthens our presence in the Greater London area and is another important step towards growing the UK network."
There are currently 31 Novotel properties in the UK and a total of 395 across 60 countries. A second new build Novotel for 2015 - a 310-bedroom property - has already been announced for Canary Wharf.
Accor has a total portfolio of nearly 3,500 hotels across 12 brands worldwide.