Due to open later this year, the hotel - which is currently under development on London's Greenwich Peninsula - features a ballroom accommodating up to 3,000 guests, a spa, and all-day dining restaurant.
The Arora Group, which will manage the hotel under a franchise agreement with the InterContinental Hotels Group (IHG), said that it is working with the Royal Borough of Greenwich, Greenwich University and the Greenwich Local Labour and Business to fill 40% of the jobs locally.
Raj Shah, commercial director of the Arora Group, said: "As a vital part of the Greenwich Peninsula regeneration project, we see tremendous value in involving the whole community as a key part of our launch programme, and that includes local partners as well as people."
Surinder Arora, chief executive and founder of the Arora Group described the hotel as "the most significant new London hotel, of this size and scale, to open in decades".
"We are committed to working with the local council, local community organisations, universities and colleges to secure the very best talent from those that share our vision and passion to make this hotel, in this exciting destination, compete on the world's stage."
The Arora Group currently operates seven hotels: Sofitel London Heathrow & Sofitel London Gatwick (under a franchise agreement with Accor), Renaissance London Heathrow (under a franchise agreement with Marriott), Holiday Inn London Heathrow - T5 (under a franchise agreement with IHG), as well as Arora London Heathrow and Arora London Gatwick/Crawley.