Starwood Hotels & Resorts Worldwide chief executive Adam Aron is to leave the business.
Aron has been in charge of the company since he was appointed interim chief executive following the departure of former president and CEO Frits van Paasschen in February.
He will become chief executive of US cinema chain AMC Entertainment Holdings, the second-largest such group in the country.
Aron's departure comes just a few weeks after it was announced that the company would be bought by Marriott International for $12.2b (£8b), making it the biggest hotel firm in the world.
Replacing Aron at Starwood will be Thomas Mangas, previously chief financial officer at the company.
"It has been a privilege to lead an extraordinary team of people around the world who, through their creativity and innovation, have changed the hospitality industry and the hotel experience in meaningful ways," Aron said in a statement.
"I am proud of what we have accomplished together with reinvigorated existing brands, the launch of new brands, accelerated growth and our game-changing merger with Marriott to soon become the biggest and best hotel company in the world."