Mark Jarvis, chef-patron of Anglo in Farringdon and Neo Bistro near Oxford Street is to open a new venture on Princes Street, Mayfair, in March.
The 35-cover Stem will be "informal, but precise in terms of its modern British food", Jarvis said.
The menus, created by Catey 2017 Newcomer Award winner Jarvis and head chef Sam Ashton-Booth, will offer dishes such as smoked eel with celeriac and white chocolate, pigeon with coconut and salted peanut, as well as pineapple, olive oil, lime and salt.
A wine list will feature about 120 wines.
The building on Princes Street is owned by the Crown Estate and is included within a regeneration project for the area.
The interior will be designed by Commercial Kitchen and Bar and will feature a living wall on ground level, and a six-seat private chef's table in the basement.
Stem will be open Monday to Saturday for dinner, Tuesday to Saturday for lunch and Sundays between 11am and 4pm.
Jarvis started working in kitchens at the age of 16. His experience includes the Lords of the Manor in the Cotswolds, Belmond Le Manoir aux Quat'Saisons in Oxfordshire, Blanc's pub, the Thatch, the Royal Exchange London and Michelin-starred Texture in London.
His first head chef role was at the Blueprint Café, where he took over from Jeremy Lee. A year later, Jarvis took on his first executive chef role at the Bingham hotel in Surrey, where he remained for two years.
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