Marriott will brand its new landmark property at London's St Pancras Chambers development as an upmarket Renaissance hotel.
The 245-bedroom Victorian hotel will include two restaurants, two bars, a health and leisure centre, ballroom and business and function facilities.
Marriott's president and managing director of international lodging, Ed Fuller, said: "The restoration of the St Pancras Chambers will herald the revival of the wider King's Cross area. We're confident that this Renaissance hotel will be a catalyst for the success of this extraordinary project."
Developer Manhattan Loft Corp will oversee the £50m restoration of the Grade 1 listed-building, which will then be managed by Marriott.
The development, which will also include residential apartments, is set to open in 2009.
By Emily Manson